منابع مشابه
Effect of tetanolysin on platelets and lysosomes.
Tetanolysin, partially purified, caused the lysis of human and rabbit platelets, as determined by a decrease in the optical density of platelet suspensions and the release of serotonin, enzymes, and protein. This lytic activity was neutralized by antitoxin. In addition, a suspension of the lysosome-containing large granule fraction of rabbit liver released hydrolytic enzymes when exposed to tet...
متن کاملIdentification of primary lysosomes in human megakaryocytes and platelets.
The presence of lysosomal enzymes in human platelets is well documented; the identity of the "lysosome," however, has been the subject of some disagreement. In order to determine the time of appearance and subcellular localization of two lysosomal enzymes in megakaryocytes (MK) and platelets, we examined normal human bone marrow and blood by electron microscopy and cytochemistry. Acid phosphata...
متن کاملLysosomes
I have followed the lysosome field since it was proposed as a concept by deDuve and his co-workers in 1955 and find this collection of papers by workers in that field an interesting addition that has many sparkling con-addition, of course, to deDuve, to name a few) but it also has several several shortcomings. For the uninitiated (and there are surprisingly many for whom "lysosome" is a new wor...
متن کاملLysosomes
Figure 1. Lysosome fusion. Lysosomes fuse with late endosomes to form endolysosomes, which are major sites of acid hydrolase activity and the digestion of endocytosed cargo. Equivalent fusions of lysosomes with phagosomes or autophagosomes can also occur (not shown in detail). Lysosomes can be reformed from endolysosomes and autolysosomes via poorly understood fi ssion and maturation processes....
متن کاملLysosomes and Membrane Recycling
A mechanism for intralysosomal membrane recycling is proposed. After invagination of the lysosomal membrane during autophagy, intralysosomal vesicles are formed. It is suggested that membrane can bleb out from these internal vesicles, probably in the form of very small vesicles, and return to the external lysosomal membrane by membrane fusion. This mechanism would conserve lysosomal membrane du...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2003
ISSN: 1538-7933,1538-7836
DOI: 10.1046/j.1538-7836.2003.t01-5-00115.x